Chemical Name:GS-441524
CAS:1191237-69-0
Synonyms; GS-441;(2R,3R,4S,5R)-2-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile;(2R,3R,4S,5R)-2-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)oxolane-2-carbonitrile;(2R,3R,4S,5R)-2-(4-AMINOPYRROLO[2,1-F][1,2,4]TRIAZIN-7-YL)-3,4-DIHYDROXY-5-(HYDROXYMETHYL)OXOLANE-2-;NUC;Remdesivir intermediates;GS-4;EVO984;GS441525;S-441524
CBNumber:CB04808604
Molecular Formula:C12H13N5O4
Molecular Weight:291.26
MDL Number:MFCD32666994
Melting point；> 233° C (dec.)
Density；1.84±0.1 g/cm3(Predicted)
storage temp. -20°C
solubility；Soluble in DMSO (>25 mg/ml)
pka；12.13±0.70(Predicted)
Appearance;White powder,tablet,liquid
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Application
Introduction
GS-441524 is the biologically active component of Remdesivir and has been widely used around the world to safely and effectively cure cats of feline infectious peritonitis (FlP) for over 18 months. FIP is a common and highly fatal disease of cats.
Function
GS-441524 is a small molecule with a scientific name of nucleoside triphosphate competitive inhibitor, which shows strong antiviral activity against many RNA viruses. It serves as an alternative substrate and RNA chain terminator for viral RNA-dependent RNA polymerase. The non-toxic concentration of GS-441524 in feline cells is as high as 100, which effectively inhibits FIPV replication in CRFK cell culture and naturally infected cat peritoneal macrophages with a concentration .
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