Name；Synephrine hydrochloride
CAS；5985-28-4
Synonyms；1-(4-Hydroxyphenyl)-2-(methylamino)-ethanol hydrochloride
N-METHYL OCTOPAMINE HCL
SYNEPHRINE HCL
SYNEPHRINE HYDROCHLORIDE
4-hydroxy-alpha-((methylamino)methyl)-benzenemethanohydrochloride
l-1-p-hydroxyphenyl-2-methylamino-1-ethanolhydrochloride
p-hydroxy-alpha-((methylamino)methyl)-benzylalcohohydrochloride
p-hydroxy-alpha-(methylaminomethyl)benzylalcoholhydrochloride
p-methylaminoaethanolphenolhydrochlorid
p-methylaminoethanolphenolhydrochloride
4-hydroxy-alpha-[(methylamino)methyl]benzyl alcohol hydrochloride
SYNEPHRINE HYDROCHLORIDE 98.0%MIN
Sympathol hydrochloride
(±)-Oxedrine hydrochloride
(±)-p-Hydroxynorephedrine hydrochloride
dl-p-Hydroxynorephedrine hydrochloride
EINECS(EC#)；227-804-6
Molecular Formula；C9H14ClNO2
MDL Number；MFCD00050566
Molecular Weight；203.67
Melting point ；147-150°C
storage temp. Refrigerator
solubility ；Methanol (Slightly), Water (Slightly）
color ；Off-White to Pale Beige
Description；
(±)-Synephrine is an alkaloid with vasoconstrictor and metabolic activities. It binds to α1A-, α2A-, and α2C-adrenergic receptors (ARs; Kis = 78, 36.7, and 24.4 μM, respectively). (±)-Synephrine is an agonist of α1A-ARs in HEK293 cells (EC50 = 4 μM in a reporter assay) but not in CHO cells expressing α2A- or α2C-AR. It also acts as an antagonist of α1A-, α2A-, and α2C-ARs, inhibiting L-phenylephrine-induced activation of α1A-AR in HEK293 cells and activation of α2A- and α2C-ARs induced by the α2-AR agonist medetomidine in CHO cells (IC50s = 12.8, 26, and 27.3 μM, respectively, in reporter assays). (±)-Synephrine induces contractions in isolated rabbit aortic rings (EC50 = 6.2 μg/ml) and increases ligation-induced mean arterial pressure in rats when administered at a dose of 2 mg/kg per day. It induces lipolysis in isolated rat and human adipocytes when used at concentrations of 100 and 1,000 μg/ml. (±)-Synephrine (50 μM) increases phosphorylation of Akt and AMP-activated protein kinase (AMPK) and translocation of Glut4 to the plasma membrane, as well as increases insulin-induced glucose consumption in L6 muscle cells when used at concentrations ranging from 25 to 200 μM.
Uses；
A α-adrenergic receptor agonist, vasoconstrictor.
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