Name:QUAZEPAM
CAS:36765-22-5
Synonyms；oniria;quazium;SELEPAM;Sch-161;sch16134;quazepam;prosedar;dormalin;She-16134;QUAZEPAM CIV
CBNumber:CB6500562
Molecular Formula:C17H11ClF4N2S
Molecular Weight:386.79
Melting point；137.5-139°
Boiling point；429.9±55.0 °C(Predicted)
Density；1.42±0.1 g/cm3(Predicted)
storage temp. -20°C
pka；0.49±0.20(Predicted)
Description
Quazepam is a rapidly acting, short term hypnotic reported to exhibit a low incidence of side effects.
Uses
Quazepam is a benzodiazepine derivative drug and is known to bind nonspecifically to benzodiazepine receptors, which affects muscle relaxation, anticonvulsant activty, motor coordination and memory. Quazepam is known to induce motor impairment and exerts hypnotic properties. Quazepam is often used for the treatment of insomina.
General Description
Quazepam (Doral) and its active metabolitesreportedly are relatively selective for the benzodiazepinemodulatory site on GABAA receptors with α1 subunitand are hypnotic agents. Quazepam is metabolized by oxidation to the 2-oxo compound and then N-dealkylation. Both metabolites are active; the first reportedly is the morepotent and selective. Thereafter, 3-hydroxylation and glucuronidationoccur.
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